Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts
نویسندگان
چکیده
Dhvanit I. Shah, Naoko Takahashi-Makise, Jeffrey D. Cooney{, Liangtao Li, Iman J. Schultz{, Eric L. Pierce{, Anupama Narla, Alexandra Seguin, Shilpa M. Hattangadi{, Amy E. Medlock, Nathaniel B. Langer{, Tamara A. Dailey, Slater N. Hurst, Danilo Faccenda, Jessica M. Wiwczar{, Spencer K. Heggers, Guillaume Vogin{, Wen Chen{, Caiyong Chen, Dean R. Campagna, Carlo Brugnara, Yi Zhou, Benjamin L. Ebert, Nika N. Danial, Mark D. Fleming, Diane M. Ward, Michelangelo Campanella, Harry A. Dailey, Jerry Kaplan & Barry H. Paw
منابع مشابه
Regulation of pre-natal haemopoiesis: evidence for negative feedback control of erythropoiesis in the foetal mouse.
The effects of medium conditioned by erythrocytes on in vitro differentiation of mouse prenatal erythroblasts were examined. Haem synthesis was inversely proportional to the concentration of erythrocyte-conditioned medium (ECM) in either presence or absence of erythropoietin (EP), but concentrations of ECM which limited haem synthesis to 50% of normal had no effect on changes in erythroblast nu...
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Mitochondrial respiratory chain disorders are characterized by loss of electron transport chain (ETC) activity. Although the causes of many such diseases are known, there is a lack of effective therapies. To identify genes that confer resistance to severe ETC dysfunction when inactivated, we performed a genome-wide genetic screen in haploid human cells with the mitochondrial complex III inhibit...
متن کاملIF1, a natural inhibitor of mitochondrial ATP synthase, is not essential for the normal growth and breeding of mice
IF1 is an endogenous inhibitor protein of mitochondrial ATP synthase. It is evolutionarily conserved throughout all eukaryotes and it has been proposed to play crucial roles in prevention of the wasteful reverse reaction of ATP synthase, in the metabolic shift from oxidative phosphorylation to glycolysis, in the suppression of ROS (reactive oxygen species) generation, in mitochondria morphology...
متن کاملThe relationship between erythropoietin-dependent cellular differentiation and colony-forming ability in prenatal haemopoietic tissues.
Levels of haem synthesis achieved by foetal liver erythroblasts responding to erythropoietin in vitro are similar in dissociated cell cultures and in cultures of organized tissues. Erythroid colony-forming cells reach maximum numbers on the sixteenth day of gestation. Their presence in foetal liver is associated with the period of most rapid production of erythrocytes, and with in vitro sensiti...
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The long form of B-cell lymphoma-x (Bcl-x(L)), an outer mitochondrial membrane protein, has been proposed to mediate the antiapoptotic action of erythropoietin on erythroid progenitor cells and to be necessary for heme synthesis in erythroblasts. Mice with conditional knockout of Bcl-x(L) (conditional bcl-x(-/-) mice) develop severe anemia that has been attributed to hemolysis and is accompanie...
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